RAD-140 (TESTOLONE)

Testolone was developed to increase muscle size, reduce fat, and boost testosterone levels.

Qty: 30 tablets

EACH TABLET CONTAINS 20MG OF RAD 140 

Supplied for Research Purposes Only

This information and product is provided for research purposes only. We do not provide any advice on the usage of these products as UK Law prevents this. Customers should check the legality of this product in their own country prior to purchase.

Benefits and uses:

Enhanced physical strength

Targeted fat burning

Endurance

Increased overall muscle mass

May be beneficial to the brain cells.

Possible protective effect against certain types of breast cancer

Dose:

20mg daily

What is RAD140 (Testolone)?

A new investigational drug called RAD140, which is also known as testolone, has recently gained popularity among bodybuilders due to their claims that it can aid in the growth of muscle tissue. The term "selective androgen receptor modulators," or SARMs, refers to the group of compounds that RAD140 is a member of [1].

Testolone, also known as RAD140, is a selective androgen receptor modulator (SARM). It acts similarly to testosterone, but its main focus is on the muscles; as a result, some people believe that it may have fewer negative side effects than testosterone or other steroids. 

In men with low testosterone levels who want to avoid testosterone replacement therapy but are looking to maintain their physical and sexual performance, RAD140 has become increasingly popular as an alternative treatment option. This use is still only supported by anecdotal evidence, as there has been no research done to substantiate it.

Studies are being conducted right now to investigate the potential role that RAD140 could play in boosting muscle mass, combating breast cancer, and safeguarding brain cells [1, 4, 5].

Bodybuilders use RAD140 to increase their strength and endurance despite the lack of research that has been done on the drug's safety in humans. Although it is not against the law, RAD140 cannot be used in competitive sports. The World Anti-Doping Agency [6] has RAD140 and all other SARMs on their list of substances that are not permitted for use.

Method of action:

The mechanism by which RAD140 accomplishes its work in the body is by selectively stimulating androgen receptors. It is known to target receptors in the bone and muscle, but studies have shown that it has very little to no effect on the reproductive organs [1].

This substance encourages the development of new muscle cells and proteins, which in turn leads to increased muscle growth [2].

There is still a lack of complete comprehension regarding the selective ability of SARMs. Some researchers believe that they may be targeting and selectively activating a different set of proteins than testosterone does. Because of this, only a select group of androgen receptors – primarily those found in the muscles – are activated [2].

The chemical structure of RAD140 is very dissimilar to that of steroid hormones like testosterone, which have a very distinct structure. Therefore, the metabolic pathways that convert testosterone into other hormones (such as oestrogen) are unable to act on testolone [1].

Some researchers have hypothesised, based on the results of an experiment carried out on rats, that RAD140 might be able to activate receptors in damaged parts of the brain. The administration of RAD140 led to an increase in MAPK activity in the brains of rats, which prevented damage to the neurons [5].

Androgen receptors in muscles can be activated by RAD140, but not in the majority of other tissues. It is believed by some researchers that this lowers the potential for testolone to cause negative side effects (in comparison to testosterone or other steroids), but additional research is required to confirm this.

Applications of RAD140:

Increasing the Amount of Muscle

The bodybuilding community is very fond of RAD140 because of the muscle-building effects that it is said to have. Some researchers believe that, much like other SARMs, it may increase muscle growth without the unwanted effects of conventional steroids [2]. These researchers believe this because it is similar to how other SARMs work.

At the moment, there is just a single animal study that looked at how RAD140 affects the process of muscle growth. During the course of the study, the researchers administered varying doses to a total of nine monkeys. After a period of 28 days, they discovered that monkeys that were given RAD140 on a daily basis had increased lean muscle mass [1].

Breast Cancer

Researchers are currently looking into RAD140 to see if there is any potential for it to act against breast cancer [4].

Hormones can trigger an aggressive form of breast cancer that is referred to as androgen and oestrogen receptor-positive, or AR/ER+ for short. SARMs and other medications that affect these receptors have been hypothesised to have the potential to fight cancer [9].

RAD140 was shown to be effective in inhibiting the effects of oestrogen in a cell-based study [4], thereby halting the progression of AR/ER+ breast cancer.

In particular, it seems that RAD140 is responsible for suppressing the ESR1 gene. This gene is accountable for the production of oestrogen receptors in the body. Estrogen loses its ability to exert its effects when there are insufficient receptors [4].

Effects on the Brain

Androgens are essential to the process of preventing damage to the brain. They have the ability to stimulate the growth of new brain cells, enhance memory, and reduce the buildup of amyloid-beta. Plaques composed of amyloid-beta protein are one of the primary contributors to Alzheimer's disease [5].

A study conducted on rats found that RAD140 protected brain nerves from damage caused by amyloid-beta plaques. In addition, RAD140 and testosterone both showed comparable levels of efficacy in inhibiting the effects of neurotoxins [5].

Some people who take RAD140 claim that it helps them sleep better, but there are no studies that support this effect. The same can be said for claims that it can improve a person's sexual performance, although this claim may be related to the fact that it mimics testosterone's effects.

Users assert that RAD140 enhances both their sleep and their sexual performance, but there have been no studies to support these claims.

Weight Loss

According to the findings of the study, RAD140 does reduce cholesterol levels. In addition, increasing muscle mass can lead to an increase in the amount of energy that is used, which can further promote fat loss. However, the combination of these factors did not result in a reduction in body fat in the one study that was conducted. As a result, there is currently no evidence to support the claim that testolone aids in the process of fat loss [1, 10].

There is currently no evidence that RAD140 is safe based on clinical trials. In spite of what some people say online, it is still possible for it to cause mood disorders, changes in sex drive, hair loss, and breast growth in men.

Inhibition of Testosterone Production and Estrogen's Effects

SARMs have the potential to inhibit the testosterone production that occurs naturally in the body. In a manner similar to that of other SARMs, it might cause a very slight elevation in blood estradiol. There are those who assert that RAD140 is unique because it does not aromatize into oestrogen nor does it inhibit testosterone production; however, there are no studies that support these assertions. In addition, feedback from customers suggests otherwise.

Both in theory and in practise, RAD140 has the potential to reduce testosterone levels while simultaneously increasing oestrogen levels. This can lead to decreased sexual desire, depression, and fatigue. Users recommend post-cycle therapy to restore hormone levels, which indicates that it is probably not as selective as some advocates claim it to be.

Prostate Risks

The negative effects that testosterone has on the prostate are one of the most significant drawbacks of using testosterone. The prostate gets larger as a result of testosterone, which may increase the likelihood of developing prostate cancer [15].

Due to the selective nature of SARMs, it is expected that they will have a minimal to non-existent effect on the prostate. According to the most recent scientific findings, RAD140 does not appear to cause an increase in the size of the prostate. Nevertheless, studies on humans have not been conducted yet, and a great number of users have reported having experiences that are inconsistent with the purported selective benefits of testolone. It is possible that adverse effects on the prostate will be found when full-scale clinical studies are conducted [1, 5].

Bioavailability

It seems that RAD140 has a high degree of bioavailability. When the drug is ingested, approximately seventy percent of it is absorbed into the body, as demonstrated by research conducted on monkeys [1].

We believe that testosterone replacement therapy – under the supervision of a licenced physician – remains a much safer alternative to taking this or any other SARM. This is based on anecdotal reports of adverse side effects, the lack of clinical studies, and the dearth of data that is currently available.

User Reviews

Some people believe that RAD140, which is an unapproved drug used as a supplement by bodybuilders, is excellent for increasing muscle mass while also reducing body fat. These people say they have heard this from other people. Some people think that it also boosts their speed, stamina, and endurance while they are exercising.

Users claim that RAD140 works quickly, with noticeable results appearing in as little as three to four weeks.

Since RAD140 suppresses testosterone production, most users choose to follow it up with post-cycle therapy (PCT).

Reference:

 Jayaraman A, Christensen A, Moser VA, Vest RS, Miller CP, Hattersley G, Pike CJ (April 2014). "Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats". Endocrinology. 155 (4): 1398–406. doi:10.1210/en.2013-1725. PMC 3959610. PMID 24428527.

 Hamson DK, Wainwright SR, Taylor JR, Jones BA, Watson NV, Galea LA (September 2013). "Androgens increase survival of adult-born neurons in the dentate gyrus by an androgen receptor-dependent mechanism in male rats". Endocrinology. 154 (9): 3294–304. doi:10.1210/en.2013-1129. PMID 23782943.

 Miller CP, Shomali M, Lyttle CR, O'Dea LS, Herendeen H, Gallacher K, et al. (February 2011). "Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140". ACS Medicinal Chemistry Letters. 2 (2): 124–9. doi:10.1021/ml1002508. PMC 4018048. PMID 24900290.

 Yu Z, He S, Wang D, Patel HK, Miller CP, Brown JL, et al. (December 2017). "Selective Androgen Receptor Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor-Positive Breast Cancer Models with a Distinct Mechanism of Action". Clinical Cancer Research. 23 (24): 7608–7620. doi:10.1158/1078-0432.CCR-17-0670. PMID 28974548.

 Hamilton E, LoRusso P, Ma C, Vidula N, Bagley RG, Troy S, et al. (2020-02-15). "Abstract P5-11-01 : Phase 1 dose escalation study of a novel selective androgen receptor modulator (SARM), RAD140, in estrogen receptor positive (ER ), human epidermal growth factor receptor 2 negative (HER2-), metastatic breast cancer". Cancer Research. 80 (4 Supplement): P5–11–01. doi:10.1158/1538-7445.sabcs19-p5-11-01. S2CID 216326672.

 Clinical trial number NCT03088527 for "Phase 1, First-in-Human Study of RAD140 in Postmenopausal Women With Breast Cancer" at ClinicalTrials.gov

 Flores JE, Chitturi S, Walker S (March 2020). "Drug-Induced Liver Injury by Selective Androgenic Receptor Modulators". Hepatology Communications. 4 (3): 450–452. doi:10.1002/hep4.1456. PMC 7049679. PMID 32140660.

 Jayaraman A, Christensen A, Moser VA, Vest RS, Miller CP, Hattersley G, Pike CJ (April 2014). "Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats". Endocrinology. 155 (4): 1398–406. doi:10.1210/en.2013-1725. PMC 3959610. PMID 24428527.

 Miller CP, Shomali M, Lyttle CR, O'Dea LS, Herendeen H, Gallacher K, et al. (February 2011). "Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140". ACS Medicinal Chemistry Letters. 2 (2): 124–9. doi:10.1021/ml1002508. PMC 4018048. PMID 24900290.