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RU-58841 is a potent DHT inhibitor, while Ketoconazole is a milder DHT inhibitor which has been shown to increase follicular thickness in medical studies. 

60ml vial with dropper.


RU58841 20mg per ml.

Ketoconazole 20mg per ml.

Supplied for Research Purposes Only

This information and product is provided for research purposes only. We do not provide any advice on the usage of these products as UK Law prevents this. Customers should check the legality of this product in their own country prior to purchase.

Benefits and uses:

Maintain a vigorous level of competition with DHT.

Accelerate the rate of cellular replication in the matrix cells.

Increase the rate of cell proliferation in the outer root sheeth cells.

Grow both the diameter and the density of your hair.

Raise the proportion of your hair that is currently in the anagen phase.

Have no unfavourable impact on the levels of hormones produced by the body

Provide net growth that is comparable to or greater than that of Finasteride

What is RU58841?

The compound known as RU58841 is an androgen receptor antagonist, also referred to as an anti-androgen. Androgenetic alopecia and acne were two of the conditions that this non-steroidal topical androgen antagonist was studied for its potential therapeutic value in. RU58841 has been shown to, in various research studies and clinical trials,

In order for RU58841 (RU-58841) to be effective, it must first bind to the androgen receptor that is present in the hair follicle. As a result, androgens do not have the opportunity to bind, which prevents them from initiating the chain reaction that leads to androgenetic alopecia and the so-called miniaturisation process. It has been shown to be possible to interrupt this hair loss message locally so that normal hair growth can continue. This has been demonstrated.

What is Ketoconazole?

Antifungal medications like ketoconazole are frequently prescribed for the treatment of fungal infections like athlete's foot and ringworm. When used topically on the scalp, it works to combat the fungus that leads to flaking and itching of the scalp (the same fungus that causes scalp infections can also hasten hair loss.)

What conclusions can be drawn from the clinical evidence?

Even though the data aren't completely conclusive, there is a substantial body of evidence suggesting that ketoconazole can assist in reducing the rate of hair loss and may even stimulate growth.

In a study that took place back in 1998 and was published in the peer-reviewed scientific journal Dermatology, the researchers found that using a shampoo containing 2 percent ketoconazole increased hair density in addition to increasing the proportion and size of hair follicles. In point of fact, it's nearly as effective as the topical treatment minoxidil, which is approved by the FDA.

Ketoconazole is known to reduce inflammation, which is one of the factors that contributes to male pattern hair loss. In 2004, researchers discovered this potential explanation for the follicle-boosting effect of ketoconazole. The combination of ketoconazole and finasteride, another treatment for hair loss that is approved by the FDA, was found to be more effective than either treatment used alone.

Since that time, researchers have continuously uncovered new evidence suggesting that ketoconazole, either on its own or in combination with another tried-and-true treatment method, is an effective treatment for hair loss. If you are interested in the specifics, this review of the relevant medical literature can provide you with more information.

We provide this compound in a form that is exceptionally stable in both solid and solution form, as was demonstrated by our research and development laboratory. This form of the compound is unique and stable in its route of synthesis. The results are very encouraging, which demonstrates that the current route of synthesis is stable for at least 24 months when it is kept at room temperature.


 "RU58841 studies and information". Anagen.

 PSK-3841 (HMR-3841, RU-58841) - AdisInsight

 Battmann T, Bonfils A, Branche C, Humbert J, Goubet F, Teutsch G, Philibert D (January 1994). "RU 58841, a new specific topical antiandrogen: a candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism". J. Steroid Biochem. Mol. Biol. 48 (1): 55–60. doi:10.1016/0960-0760(94)90250-X. PMID 8136306. S2CID 31052540.

 Münster U, Nakamura C, Haberland A, Jores K, Mehnert W, Rummel S, Schaller M, Korting HC, Zouboulis C, Blume-Peytavi U, Schäfer-Korting M (January 2005). "RU 58841-myristate--prodrug development for topical treatment of acne and androgenetic alopecia". Pharmazie. 60 (1): 8–12. PMID 15700772.

 Van Dort ME, Jung YW (April 2001). "Synthesis and structure-activity studies of side-chain derivatized arylhydantoins for investigation as androgen receptor radioligands". Bioorg. Med. Chem. Lett. 11 (8): 1045–7. doi:10.1016/s0960-894x(01)00146-9. PMID 11327585.

 Poulos GA, Mirmirani P (February 2005). "Investigational medications in the treatment of alopecia". Expert Opin Investig Drugs. 14 (2): 177–84. doi:10.1517/13543784.14.2.177. PMID 15757393. S2CID 24694921.

 Elancheran, R.; Maruthanila, V. L.; Ramanathan, M.; Kabilan, S.; Devi, R.; Kunnumakara, A.; Kotoky, Jibon (2015). "Recent discoveries and developments of androgen receptor based therapy for prostate cancer". MedChemComm. 6 (5): 746–768. doi:10.1039/C4MD00416G. ISSN 2040-2503. S2CID 72654573.

 Leonard, Matthew J.; Lingham, Anthony R.; Niere, Julie O.; Jackson, Neale R. C.; McKay, Peter G.; Hügel, Helmut M. (2014). "Alternative synthesis of the anti-baldness compound RU58841". RSC Adv. 4 (27): 14143–14148. Bibcode:2014RSCAd...414143L. doi:10.1039/C4RA00332B. ISSN 2046-2069.

 Cousty-Berlin D, Bergaud B, Bruyant MC, Battmann T, Branche C, Philibert D (October 1994). "Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: relation of their systemic activity to the formation of a common metabolite". J. Steroid Biochem. Mol. Biol. 51 (1–2): 47–55. doi:10.1016/0960-0760(94)90114-7. PMID 7947350. S2CID 29752252.

Topical ketoconazole for the treatment of androgenetic alopecia: A systematic review Jaime R. Fields BS,Peter M. Vonu BS,Reesa L. Monir MD,Jennifer J. Schoch MD First published: 20 December 2019 6

Seems effective so far.


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