MK-677 

MK-677 is a growth hormone secretagogue. 

Qty: 30 tablets

EACH TABLET CONTAINS 25MG OF MK 677 

Supplied for Research Purposes Only

This information and product is provided for research purposes only. We do not provide any advice on the usage of these products as UK Law prevents this. Customers should check the legality of this product in their own country prior to purchase.

WHAT  IS MK-677 (IBUTAMOREN)?

The compound MK-677, which also goes by the name ibutamoren, stimulates the production of growth hormone (GH) and raises levels of insulin-like growth factor 1. (IGF-1). Ibutamoren mimics the function of the hormone ghrelin and binds to one of the ghrelin receptors (GHSR) in the brain, which causes a rise in the amount of growth hormone in the body.

The secretion of growth hormone from the brain is prompted by activation of the GHSR. Only the effects of ibutamoren on hunger are described in clinical investigations; thus, as was to be predicted, ibutamoren, like ghrelin, causes an increase in appetite. GHSR is located in areas of the brain that are responsible for regulating appetite, pleasure, mood, biological cycles, memory, and cognitive function.

As a result, we should be prepared for the possibility that ibutamoren will also have an effect on these functions. It raises levels of growth hormone while having a negligible or non-existent effect on other hormones such as cortisol. It is generally not a good idea to have an excessive level of this hormone because elevated cortisol levels can depress the immune system, slow the healing of wounds, and impair learning and memory.

MK-677 BENEFITS AND RESULTS

In addition to its anti-aging effects, MK-677 can help users increase the quality of their sleep, grow muscle, slow the breakdown of muscle tissue, and get a better night's rest. There is some evidence that it also has nootropic properties, and using it to treat growth hormone deficits can be advantageous. Continue reading for a more in-depth examination of these advantages.

Promotes the Growth of Muscle.

Ibutamoren is commonly used as an anabolic drug, which means it is utilised to increase the amount of lean body mass in the body. It can be taken orally and only needs to be done so once per day. MK-677 has been shown to activate both growth hormone and insulin-like growth factor-1, both of which play important roles in the preservation of lean body mass. Many people have the belief that an increase in Growth Hormone will encourage an increase in muscle size and strength. Because MK-677 has the ability to increase production of Growth Hormone, it has become a popular option.

An injectable version designed to boost growth hormone resulted to enhanced muscle strength in the thighs of people who were 60 years old, according to the findings of one research study. When it comes to MK-677's ability to stimulate muscle growth, the drug's effects will differ from person to person based on their current workout routine as well as any pre-existing medical conditions they may have.

Another trial with 24 obese individuals found that a therapy of ibutamoren for two months resulted in an increase in lean mass as well as a transitory increase in basal metabolic rate (BMR)

Helps Prevent the Loss of Muscle

Recent research has revealed that taking MK-677 can help prevent the loss of muscle mass that might occur when an individual's diet contains less protein than it did previously. The results of a study that examined the effectiveness of MK-677 in reversing protein catabolism in young, healthy adults were found to be highly encouraging. This study involved a group of participants. As a consequence of this, it has been hypothesised that MK-677 could serve as an efficient treatment for people who are afflicted with catabolic disorders.

Bone density is increased as a result.

According to the findings of a number of research, administration of MK-677 over an extended period of time may produce extremely beneficial effects on bone mineral density. This discovery may be of value to many different groups of people, including people who are overweight, elderly persons, and women going through menopause. These unique populations can experience harmful health problems as a result of low bone mineral density, and MK-677 has been shown to be a successful treatment for many of these conditions.

Ibutamoren was shown to accelerate bone turnover in a study with 24 healthy obese male volunteers.

Ibutamoren was found to promote bone growth in 187 senior persons (65 years or older), as determined by osteocalcin, a marker of bone turnover that was assessed in many investigations.

Ibutamoren was shown to enhance bone mineral density in a research involving 292 post-menopausal women, which contributes to increased bone strength and helps prevent osteoporosis.

Because gains in bone density often take more than a year of use, the groups of people who stand to benefit from MK-677's potential to do so must do research into the probability of any long-term negative effects.

Improves Sleep

It is usually believed that Ibutamoren Mesylate can assist with sleep quality because it increases production in Growth Hormone. This is on account of the fact that it is known that Growth Hormone can help improve the quality of one's sleep.

Ibutamoren was shown to increase sleep quality as well as the amount of time spent in REM (rapid eye movement) sleep in a research that included both younger and older participants.

In addition to the findings of scientific studies, there have been several accounts of individuals experiencing a subjective increase in the quality of their sleep.

Fights the Signs of Aging and May Lead to an Increase in Longevity

Once a certain age is reached, the body's production of growth hormone begins to naturally and gradually decrease in the same way that other hormones in the body do. Taking MK 677 can be beneficial for those who are becoming older because it causes a rise in growth hormone and insulin-like growth factor 1 in the body after ingestion. People who are above the age of 60 and take MK-677 can improve their overall hormone profiles by increasing their GH levels (Growth Hormone levels), so compensating for their naturally dropping GH levels.

Ibutamoren, when taken on a daily basis, was able to raise levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) to that of healthy young people in a trial involving 65 old men and women.

Ibutamoren was able to revitalise the growth hormone profile in another investigation that involved 24 obese individuals.

Could Have Nootropic Effects On The Brain

It is believed that MK-677 can have the same effects on the brain that Ghrelin does due to the fact that it attaches to the same receptors as Ghrelin does. MK-677 also has a lot of properties that are comparable to Ghrelin.

On the other hand, there are no studies that can definitively state whether or not MK-677 has direct nootropic effects on the brain. In spite of this, researchers are keeping their fingers crossed that MK-677's beneficial effects on cognitive function can be traced down to a few detectable indirect mechanisms. In retrospect, the capacity of Ibutamoren to enhance REM sleep and hence improve overall sleep quality stands out as an approach that demonstrates considerable potential.

When one is working towards achieving appropriate cognitive function, it is of the utmost importance to ensure that one gets the recommended amount of sleep each night. The capacity of individuals to obtain a decent night's rest is one of the ways in which the use of MK-677 can help improve cognitive performance. Because IGF-1 plays a role in cognitive function, MK-677's capacity to boost IGF-1 synthesis can also indirectly improve cognitive function because of the role IGF-1 plays in cognitive function. According to the findings of one study, participants' levels of IGF-1 were favourably correlated with their ability to do well on cognitive tasks. It is common knowledge that adequate sleep is necessary for healthy cognitive function.

Helpful in the Management and Cure of Growth Hormone Deficiency

Ibutamoren has the potential to raise levels of growth hormone, as well as IGF-1 and IGFBP-3, in children who are short on growth hormone. The amounts of prolactin, glucose, triiodothyronine (T3), thyroxine (T4), thyrotropin, cortisol, and insulin do not change while these effects are still brought about.

Ibutamoren caused an increase in IGF-1 and growth hormone production in males with severe GH deficiencies, but it had no discernible effect on the levels of cortisol, PRL, or thyroid hormone. Despite this, insulin and glucose levels rose significantly.

POSSIBLE ADVERSE REACTIONS TO MK-677

MK 677 has not been shown to generate a large number of adverse consequences for its users, although there is a possibility that some populations will experience adverse effects as a result of its use.

When taking MK-677, individuals who are at risk for developing insulin sensitivity or who are already diagnosed with diabetes may be at risk. The use of MK 677 has the potential to make symptoms that are connected with the aforementioned disorders even more severe. MK-677, like any other substance, must be dosed and used appropriately in order to achieve the desired effects. The dosage was the most important variable in the research that looked at how MK-677 promotes muscle mass. The adverse effects of MK-677 are almost always caused by one of two factors: either an incorrect dosage or prolonged use of the drug.

The reported adverse effects of MK-677 are almost often caused by abnormally high levels of growth hormone in the body, which are the result of taking too much of the drug too frequently. These adverse effects include the following:

A more ravenous appetite

Lethargy

If you have a history of medical issues or abnormally high hormone levels, you may experience joint pain.

Insulin resistance

Possible rise in prolactin levels, which are able to be managed by the patient

When taken in the recommended dosage, the negative effects of MK-677 are extremely rare, if they do occur at all, in comparison to the positive outcomes that can be achieved by doing so.

CONCLUSION

It has been demonstrated that MK-677 can provide several health benefits to persons who suffer from specific illnesses. MK 677 can be of considerable use to people who have conditions that cause catabolism, low bone density, and difficulties sleeping at night. It can also help people who have trouble sleeping during the day.

It has been demonstrated that the capacity of the MK 677 secretagogue to efficiently produce growth hormone and insulin-like growth factor-1 makes it a suitable instrument for a wide variety of different populations. Numerous studies have demonstrated that those of advanced age, those who are obese, those who have trouble sleeping, those who have inadequate bone density, and others can benefit from taking MK 677. MK 677 has the potential to be a useful tool for these groups in the fight against problems that can be caused, in large part, by a deficiency of growth hormone and insulin-like growth factor-1.

References:

J Clin Endocrinol Metab. 1998 Feb;83(2):320-5. MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism. Murphy MG1, Plunkett LM, Gertz BJ, He W, Wittreich J, Polvino WM, Clemmons DR

J Clin Endocrinol Metab. 1996 Dec;81(12):4249-57. Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects. Chapman IM1, Bach MA, Van Cauter E, Farmer M, Krupa D, Taylor AM, Schilling LM, Cole KY, Skiles EH, Pezzoli SS, Hartman ML, Veldhuis JD, Gormley GJ, Thorner MO.

MK-677, an Orally Active Growth Hormone Secretagogue, Reverses Diet-Induced Catabolism. M. G. Murphy L. M. Plunkett B. J. Gertz W. He J. Wittreich W. M. PolvinoD. R. Clemmons. The Journal of Clinical Endocrinology & Metabolism, Volume 83, Issue 2, 1 February 1998, Pages 320–325

Neuroendocrinology. 1997 Oct;66(4):278-86. Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man. Copinschi G1, Leproult R, Van Onderbergen A, Caufriez A, Cole KY, Schilling LM, Mendel CM, De Lepeleire I, Bolognese JA, Van Cauter E.

Br J Pharmacol. 2008 Jun; 154(3): 557–568. Regulation of muscle mass by growth hormone and IGF-I. C P Velloso

J Clin Endocrinol Metab. 1998 Feb;83(2):362-9. Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure. Svensson J1, Lönn L, Jansson JO, Murphy G, Wyss D, Krupa D, Cerchio K, Polvino W, Gertz B, Boseaus I, Sjöström L, Bengtsson BA

J Bone Miner Res. 1998 Jul;13(7):1158-66. Treatment with the oral growth hormone secretagogue MK-677 increases markers of bone formation and bone resorption in obese young males. Svensson J1, Ohlsson C, Jansson JO, Murphy G, Wyss D, Krupa D, Cerchio K, Polvino W, Gertz B, Baylink D, Mohan S, Bengtsson BA

J Clin Endocrinol Metab. 2001 Mar;86(3):1116-25. Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women. Murphy MG1, Weiss S, McClung M, Schnitzer T, Cerchio K, Connor J, Krupa D, Gertz BJ; MK-677/Alendronate Study Group

J Clin Endocrinol Metab. 1999 Feb;84(2):471-5. Insulin-like growth factor-I and cognitive function in healthy older men. Aleman A1, Verhaar HJ, De Haan EH, De Vries WR, Samson MM, Drent ML, Van der Veen EA, Koppeschaar HP

Clin Pharmacol Ther. 2001 Jul;70(1):91-8. Effects of oral administration of ibutamoren mesylate, a nonpeptide growth hormone secretagogue, on the growth hormone-insulin-like growth factor I axis in growth hormone-deficient children. Codner E1, Cassorla F, Tiulpakov AN, Mericq MV, Avila A, Pescovitz OH, Svensson J, Cerchio K, Krupa D, Gertz BJ, Murphy G.

J Clin Endocrinol Metab. 1997 Oct;82(10):3455-63. Oral administration of growth hormone (GH) releasing peptide-mimetic MK-677 stimulates the GH/insulin-like growth factor-I axis in selected GH-deficient adults. Chapman IM1, Pescovitz OH, Murphy G, Treep T, Cerchio KA, Krupa D, Gertz B, Polvino WJ, Skiles EH, Pezzoli SS, Thorner MO